Silver Sulfadiazine: Effect on the Ultrastructure of Pseudomonas aeruginosa

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Silver sulfadiazine: effect on the ultrastructure of Pseudomonas aeruginosa.

Pseudomonas aeruginosa exposed to silver sulfadiazine (AgSu) were examined in an electron microscope. The treated cells were distorted in shape, and structures (blebs) protruded from the cell surface. These "blebs" appeared to arise from the cell wall. A strain of P. aeruginosa resistant to AgSu did not display these changes. Upon exposure of P. aeruginosa to silver nitrate, none of these chang...

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Even though the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. AgSu blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action. The ribosomes, ribonucleic acid, and DNA isolated from treate...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1973

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.3.5.621